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Systemic Enzymes vs. NSAIDs
for Pain & Inflammation
By Doctor’s Prescription for Healthy Living


Systemic Oral Enzymes vs. NSAIDs

Based on a thorough review of the pertinent literature, international experts have come up with the following guidelines to explain the benefits of systemic enzymes to you and your doctor.

  • Systemic oral enzymes are not a drug. They support healthy processes.
  • Systemic oral enzymes have no side effects (in contrast to NSAIDs).
  • The benefits may take time; however, after discontinuation the beneficial effect continues for several weeks (in contrast to NSAIDs).
  • All joint conditions can benefit from systemic oral enzymes. The clinical efficacy of systemic oral enzymes has been demonstrated in different locations of the body: hip, knee, finger, and spine.
  • Virtually all common stages and types of joint conditions can receive health support, even very late ones. Ideally, early cases should result in stabilized cartilage metabolism and joint function.
  • Patients of all ages can use.
  • Systemic oral enzymes have a preventive effect.
  • The time for surgery can be temporarily postponed in case surgery is necessary. After the intervention of systemic oral enzymes, the regeneration of the joint tissues and cartilage may well ensue.

Wobenzym N & Joint Health

In the case of arthritis, we recognize that the use of aspirin and related drugs provides safe, effective relief for millions of people who have occasional, short-term arthritis pain and swelling. However, continuous use of non-steroidal anti-inflammatory drugs (NSAIDs) for long-term pain conditions can lead to severe gastrointestinal problems in many cases. Some 15,000 to 20,000 people die each year and over 100,000 are hospitalized due to ulcers and other stomach problems caused by aspirin and NSAIDs.

Wobenzym N, the world’s most thoroughly researched systemic enzyme preparation, has been, for many years, second only to aspirin in sales in Germany and was ninth overall for sales among all “drugs” in that country. The only difference, of course, is that Wobenzym N is an all-natural preparation. It is a non-drug, simply a combination of five potent systemic enzymes.

A recently completed study on experimentally induced rheumatoid arthritis provides clear-cut evidence that systemic oral enzymes not only are highly effective—they can aid in preservation of afflicted joint tissue. In the study, published in the Journal of Rheumatology (28;9:2049-59), systemic oral enzymes were shown to offer strong protection to the joint matrix. In this case, rheumatoid arthritis was experimentally induced by collagen injections. Support consisted of a systemic oral enzyme preparation (made by the same company that manufactures Wobenzym N and closely related to Wobenzym N), ibuprofen, or a placebo for four weeks, while one group received no collagen and thus maintained normal joint health.

Measurements and x-rays were used to examine redness, swelling and overall joint tissue health. While swelling and redness were similarly reduced in both the enzyme and ibuprofen groups, the group receiving the enzymes experienced superior joint health with a smooth layer of cartilage with thickness comparable to the group without experimentally induced arthritis. One of the lead investigators for the study, Steve Emancipator, M.D., professor of pathology at Case Western Reserve University, Cleveland, Ohio, previously reported similar findings in the International Journal of Immunotherapy in 1997, at which time his research team concluded that the systemic oral enzyme preparation “protects articular cartilage significantly better than ibuprofen in this… model of rheumatoid arthritis, despite equal anti-inflammatory potency.”

Translated into human health implications, that means systemic oral enzymes are able to help preserve joint tissue.

With Wobenzym N, we also have great clinical results.

Clinical Results – Osteoarthritis

In one study among 80 osteoarthritis patients, Wobenzym N was pitted against the NSAID diclofenac. Patients received either seven coated Wobenzym N tablets four times daily and two capsules of placebo or seven coated tablets of placebo four times daily and two 50 mg capsules of diclofenac. The groups were similar with respect to symptoms. An evaluation of all principal criteria examined revealed equivalent therapeutic results in both groups after four weeks.

Meanwhile, an Austrian study found systemic oral enzymes provide safe, effective support for osteoarthritis. Researchers studied 73 patients who had osteoarthritis of the knee. After three weeks, overall reduction in pain was similar in both groups. The study, conducted by Drs. G. Klein and W. Kullich of the Rehabilitation Center for Rheumatic and Cardiovascular Diseases, Saalfelden, Austria, was published in July 2000 in Clinical Drug Investigations.

When it came to measuring pain and knee function using the standard Lequesne index, both groups improved continuously and equally, according to statistical evaluation. The researchers concluded, “Short-term evaluation indicates that oral enzymes may be considered an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful gonarthritis.”

The authors reported no gastrointestinal problems with the systemic enzyme formula. Many other peer-reviewed clinical studies have shown that the product has no serious side effects and is extremely safe, even when taken in large quantities or for long periods of time.

The Austrian study is the latest to confirm the health benefits of Wobenzym N and related systemic enzymes, not only for health support among people with osteoarthritis, but also in rheumatoid and other cases of immune-related arthritis.

Clinical Results – Rheumatoid Arthritis

In Eilat, Israel, at the International Congress for Advances in Immunology and Allergology at the Threshold of the XXI Century, held from May 3-6, 2000, additional clinical results confirm use of Wobenzym N for rheumatoid arthritis. This study enrolled 60 patients with confirmed diagnosis of rheumatoid arthritis.

Thirty patients received seven tablets of Wobenzym N tablets, three times per day, while another 30 patients received a weekly dose of 7.5 mg of methotrexate, a drug used to control severe rheumatoid arthritis. The majority of the patients in both groups also received diclofenac (100 to 150 mg per day), while some patients received the corticosteroid prednisone.

The onset of therapeutic effect (diminishing of the pain intensity, morning rigidity, reduced inflammatory and immune activity) with Wobenzym N was observed as early as one to two months after the beginning of the therapy, while in the control group the same effect was observed only after three to four months. Use of Wobenzym N instead of methotrexate resulted in equivalent healing results. In the majority of patients of both groups, no x-ray or ultrasonographically confirmed progress of the disease was observed.

Clinical Results – Ankylosing Spondylitis

Ankylosing spondylitis is a severe, inflammatory arthritis of unknown cause. It can make your life miserable by giving you severe back pain, often moving into the middle and upper back area all the way up to the neck, sometimes to the point where movement in any direction is severely limited; for the sufferer, even turning his head, bending, or stooping may be difficult, if not nearly impossible, to do without great pain. Early morning stiffness and many other physical limitations accompany this condition.

In its advanced form, almost total immobilization of the spine can occur, resulting in what’s called the straight “poker spine.” This very painful condition affects some 300,000 people and is especially common in men. Activity and pain relievers are probably the best antidote to this troubling, all too often debilitating condition. If the condition becomes severe, the sufferer’s posture may become deformed.

Reports have been made concerning the positive influence of oral enzymes on ankylosing spondylitis. In 1980, Dr. H. Reinbold reported of his astonishing 35-year-old patient with the condition whose complete remission had persisted for at least 12 years.

This report and other case histories which have also progressed similarly led Dr. K.M. Goebel to test the effect of the enzyme formula Mulsal, an oral enzyme formula also manufactured by Mucos Pharma GmbH, makers of Wobenzym N, and very similar in composition to Wobenzym N. In this study, the oral enzyme preparation was compared with indomethacin in a randomized, clinical, double-blind study on 40 patients with this painful condition.

The cumulative pain scores were evaluated statistically at the end of therapy. The analgesic potency of the enzymes was found to be less than that of the NSAID at the beginning of therapy—but was found to be significantly superior after three months of therapy. The tolerance of the enzyme preparation rated by physicians and patients was “good,” whereas tolerance was found to be “moderate” for the NSAID.

The New COX-2 Inhibitors

When tens of millions of patients take any medication there will be reports of unusual adverse health events seen simply because these serious problems will occur in any large population with or without medication. Proving they are caused by use of that medication under these circumstances is often most difficult. However, when they are serious or life-threatening events, they certainly cannot be ignored.

NSAIDs, including the newer COX-2 inhibiting drugs like Vioxx and Celebrex, have, however, much more common and, at times, serious side effects such as gastric ulcers, gastrointestinal bleeding, kidney dysfunction or failure, and allergic reactions, among many problems.

It is important to recognize that what you bring to the medication in terms of your own health risks clearly is a major factor in deciding if your personal safety is at risk. Thus, if you have had previous gastric ulcers or are elderly, have had kidney problems or require many other medicines such as blood pressure tablets and diuretics (water pills), you should discuss this with your own doctor or health advisor.

Appropriate Systemic Enzyme Use

So, it is on this basis that many doctors including allopathic and naturopathic can now recommend to patients systemic oral enzymes. However, keep in mind, despite their international recognition as therapeutic agents, systemic enzymes are sold as a dietary supplement in the United States where the only claims that can be made are those for supporting health. This is a very positive way of using them, too. In the context of health support, using systemic oral enzymes makes a lot of sense. We suggest working with a qualified doctor or health professional if you wish to use systemic oral enzymes and you are using other drugs or medications for a health condition.

Suggested Dosage

To utilize Wobenzym N for joint health, product recommendations are to take 3 to 5 tablets, 2 to 3 times daily, in between meals. But for more difficult situations, increasing your morning dosage to 10 to 15 Wobenzym N tablets, followed by smaller amounts two or more times during the day can be more therapeutic.


For more product information on the Wobenzym N, click here.


Article: “Wobenzym N – 29 Million People Already Know This Secret”

Article: “Is Your Body Secretly on Fire with Inflammation? A Simple Blood Test Can Tell”


The statements contained in this article have not been evaluated by the Food and Drug Administration. The information contained here is not intended to diagnose, treat, cure, or prevent any disease. Suggestions and ideas presented in this document are for information only and should not be interpreted as medical advice, meant for diagnosing illness, or for prescriptive purposes. Readers are encouraged to consult their health care provider before beginning any cleanse, diet, detoxification program, or any supplement regimen. The information in this document is not to be used to replace the services or instructions of a physician or qualified health care practitioner.

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The statements contained on these pages have not been evaluated by the Food and Drug Administration. The information conained here is not intended to diagnose, treat, cure, or prevent any disease. Suggestions and ideas presented in this document are for information only and should not be interpreted as medical advice, meant for diagnosing illness, or for prescriptive purposes. Readers are encouraged to consult their health care provider before beginning any cleanse, diet, detoxification program, or any supplement regimen. The information in this document is not to be used to replace the services or instructions of a physician or qualified health care practitioner.


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