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The Big Calm and the Science of the New Thermogenesis
by Randi Clausen – Healthy Living Article

Thermogenesis Defined

The term “thermogenic” is euphemistically referred to as “fat burning” because of the nature in which the process works.

In thermogenesis, the metabolic rate of cells is increased, requiring them to “burn” fat that the body stores in adipose tissue. This is completed when the conversion of nutrients (such as fat) to energy occurs within the cells, more specifically, inside cell structures called mitochondria.

Basically, the health media has told consumers about only one type of thermogenesis, the one that is known for its use of stimulants. The other is all about the big calm. The big calm is the new way to lose weight.

Actually, both types of thermogenesis have a place in the dietary supplement category. For example, in the stimulant category, bitter orange from immature fruits has been used for thousands of years in Chinese medicine, thanks to its synephrine, and it can be found in many diet formulas.

Coffee can also be a dieter’s friend, but comes with a mildly addictive central nervous system stimulation, which can cause some to be jittery.

From the Amazon rainforest comes guarana, whose rich caffeine phytochemicals are actually defensive toxins that repel biological pathogens. Guarana is in all sorts of teas and soft drinks as well as dietary supplements.

However, the big daddy of all excitants is Ephedra sinensis, also known as Ma Huang. This metabolic stoker was extremely popular throughout the ‘90s until the natural products industry and federal regulators worked together to curb its use due to its abuse by dieters and thrill seekers.

Many of these metabolic stokers can increase blood pressure and heart rate. This is the side to be careful about and why anybody considering using this type of weight-loss aid should consult a qualified health professional. Plus, you might want to consider what we're about to tell you.

The Calm Thermogenesis

The modern breakthrough in thermogenesis now reaching the consumer offers an entirely different non-stimulant experience and actually stokes only the mitochondria of fat cells, promotes overall health and most of all does not affect the same receptors as the stimulant supplements do. You get the metabolic stoking, yet calm fire.

Specifically speaking, the thermogenesis induced by an extract of brown seaweed called fucoxanthin is non-stimulant in nature because it bypasses the adrenergic (stimulatory or sympathetic) receptors at the surfaces of the cells.

This is pretty major stuff. The adrenergic receptors bind with adrenaline and noradrenalin (the stress hormones called epinephrine and norepinephrine in the United States), and are activated by other chemicals that bind to them, including caffeine and ephedrine

Unlike the stimulants, fucoxanthin selectively activates mitochondria precisely where conversion of fat into energy takes place, particularly in the fat cells found in the belly.

Fucoxanthin is particularly effective at “burning” visceral fat, which is composed of white adipose tissue. Visceral fat is the fat surrounding the internal organs and specifically the double layer of fat flanking the stomach, called the omentum. This is different from subcutaneous fat, which lies just below the surface of the skin and is more often deposited in the hip and thigh regions. An excess of visceral fat leads to the “pot belly” or “beer belly” effect in which the abdomen protrudes excessively.
In a Japanese study, researchers determined that supplementation with fucoxanthin dramatically reduced the abdominal fat of mice. The extract accomplishes this by igniting the production of a specialized protein gene called uncoupling protein-1 (UCP1 gene) in white adipose tissue. The researchers believe that the UCP1 gene unleashes fats and makes them more available for energy. This speeds their oxidation and results in burning the visceral fat tissue. Yet, it does so without affecting the central nervous system.


The most well-known and number-one brand of fücoxanthin is fücoTHIN from Garden of Life. Jordan Rubin, founder of Garden of Life, has worked with thousands of Americans one-on-one to lose weight, as documented in his book Perfect Weight America, and this particular supplement, he says, arguably played a critical role in their weight loss, which also included improved shopping skills and dietary changes. Jordan clearly loves telling the story of his discovery of this fat burner.

“Whenever I tell someone the story of fücoTHIN, there is almost always the same reaction. I tell them that the product is a fat burner, and they roll their eyes. After all, there are hundreds of products that tout their ability to burn fat or raise your metabolism. But something funny happens as I continue the story. You see, the story of fucoxanthin, the main ingredient contained in fücoTHIN, reads like an action adventure novel. There are exotic locales, cutting- edge science, stories of ancient cultures, a dedicated Russian doctor, and even a sad, tragic and untimely death. All of a sudden, people were becoming more and more interested.”

Of particular importance to the story of fücoTHIN was Jordan’s close working friendship with the classically trained biochemical and plant physiologist Dr. Zakir Ramazanov, who served as the Head Engineer at the Institute of Solar Energy of the Soviet Union.

It was there that Dr. Ramazanov began experimenting with solar bioreactors and how they affected the cultivation of certain marine vegetables and algae, including spirulina and chlorella. As his career advanced and eventually took him to the United States, Dr. Ramazanov continued to develop cultivation methods that allowed for the human consumption of sea vegetables more commonly known as seaweed.

So why did Dr. Ramazanov give his full attention to seaweed?

“Dr. Ramazanov focused on seaweed based upon epidemiological data from some of the longest lived and healthiest cultures on the planet. Scientists have found compelling data that links the consumption of seaweed to the long-term health of many Asian cultures, most notably the Japanese. It is amazing to me how often we ignore data like this. Instead of following the health secrets of the longest living peoples, we opt for convenience foods such as greasy fries and mocha lattes and then wonder why we are getting fatter and sicker. We even feel hopeless as to why. The answers are right in front of us! Dr. Ramazanov understood that key components of the Asian diet, namely seaweed, contributed to their extraordinary health. He was determined to bring this message to the world.”

Eventually, Dr. Ramazanov would move to the Canary Islands where he would work for the Institute of Technology and Marine Sciences. While living there, fucoxanthin, the brown seaweed extract with the ability to burn fat, caught Dr. Ramazanov’s attention, which would ultimately lead to it becoming the main ingredient in fücoTHIN.

Of course, every story has a climax and a resolution that both grabs and satisfies the person hearing the story. For fücoTHIN it is this: It works. It burns fat, and clinical research shows that it does so without all of the harm that other fat-burning formulas cause.

Dr. Ramazanov’s theories were tested in two separate studies, both performed by a highly reputable and independent third-party research institute.

Dr. Ramazanov died unexpectedly before he could see fucoxanthin made available for mass consumption. However, the light of his scientific findings continues to shine brightly.


A total of 150 women participated in these studies: 40 in the Metabolic Rate Study and 110 in the Weight Loss Study. The average age of the women in the group was 38, and all participants were clinically obese. Both studies lasted 16 weeks, and in both all the participants were counseled to follow a 1,800-calorie diet. Because there was a particular interest in fucoxanthin’s effects on white adipose tissue that comprises human visceral fat, the groups within the weight loss study were further broken down into two sub-groups: (1) those with non-alcoholic fatty liver disease (NAFLD), and (2) those who had normal liver fat (NLF).

The Metabolic Rate Study concluded that there was a statistically significant difference between the group taking the fücoTHIN and the placebo control group. They found:

  • The group taking fücoTHIN experienced an increase in energy expenditure rate (also known as metabolic rate) of 7.03 units Kelvin as measured at the conclusion of the 16-week study. The placebo group experienced an increase in energy expenditure of 5.95 units Kelvin. Therefore, the group taking fücoTHIN had a metabolic rate increase that averaged 18.2 percent higher than the placebo group.
  • Researchers first noted an increase in human metabolic rate after the fifth full week of the study.

The Weight Loss Study made similar statistically significant findings:

  • There were two groups who took fücoTHIN in this study: those with NAFLD and those with NLF. The group with NAFLD lost an average of 15.2 pounds while the group with NLF lost an average of 13.9 pounds. The average of both groups, which is the entire study group taking the formula, lost an average of 14.5 pounds.
  • The placebo group only lost three pounds.
  • Mathematically, those who took fücoTHIN lost over 4.5 times more weight than those who just dieted.
  • In addition, waist circumference was significantly reduced in those taking the formula versus the placebo.
  • The study determined that fücoTHIN promotes weight loss and body and liver fat content reduction in obese non-diabetic female subjects independently of their liver fat content.
  • The first “statistically significant reduction in body weight” occurred after six continuous weeks of supplementation.
  • Researchers concluded that “the results of this clinical trial indicate that [fücoTHIN] possesses clinically relevant anti-obesity properties.”

When I first heard of brown seaweed and weight loss a few years ago, I went out and bought a big package of brown seaweed and ate the whole darned thing. I could feel more energy, definitely, and, of course, seaweed is truly one of the great sources of vitamins and minerals. Indeed, like the sea itself, seaweed is a rich source of all our minerals, especially iodine for the thyroid, but also for long-chained polysaccharides that help the body to excrete chemical toxins including radiation.

Not everyone has a taste for seaweed, though. Well, fücoTHIN changes the whole dynamic, and it’s the brand you want to buy. It has the best track record and delivers the highest potency.

Identifying and measuring the amount of fucoxanthin in products

This is really important these days because, well, a lot of knock-off products have come on the market. However, there are different ways of identifying and measuring the amount of fucoxanthin in products. Most companies do not measure only fucoxanthin but other carotenoids as well when they do their laboratory testing, inflating their product potency. The fücoTHIN formula is not only based on the pioneering work of Dr. Ramazanov but is measured using a laboratory method that allows for precise identification of fucoxanthin. There’s a big difference, too, as to how many capsules of other products would equal two of fücoTHIN.

Recently, The Doctors’ Prescription for Healthy Living obtained a letter from Craft Technologies, Inc. (CTI), a testing laboratory that specializes in the analysis of nutrients, carotenoids, vitamins, bioflavonoids, and phytochemicals. The management team has over 50 years of combined experience in nutritional analysis and method development. Dr. Neal Craft, president, has been involved in the development of methods for the measurement of vitamins, carotenoids and phytochemicals in biological materials since 1984. Many companies are using what is known as UV or ultraviolet testing for fucoxanthin, he said. Dr. Craft argues that the accurate measurement of fucoxanthin concentration should be determined by high-performance liquid chromatography (HPLC) near 450 nm wavelength—the wavelength at which fucoxanthin has maximum absorbance.

However, UV is the method of choice used by many suppliers of fucoxanthin products from around the world, he adds. “This method [of] approach delivers consistently false results since it is not measuring only fucoxanthin. Only those who desire an accurate measure of their product’s content and quality use the HPLC method to verify fucoxanthin concentration.”

According to the report, a version of which also appeared in the 2008 issue of the FASEB Journal (22:1105.1-1105), none of the other products tested “registered more than a trace presence of fucoxanthin.” The only product that actually contained what its label stated and in amounts recommended for effective weight management was fücoTHIN from Garden of Life.

Because it supplies actual quantifiable amounts of fucoxanthin, fücoTHIN can be characterized as a non-stimulant, weight-management supplement with a thermogenic effect for fat metabolism. It’s the real thing, it’s modern non-stimulatory thermogenesis—and that’s a good thing. fücoTHIN is the calm approach to sensible weight loss.


Note: The content provided in this article is intended for informational and educational purposes only and is not intended to take the place of professional medical advice. You are encouraged to consult with your medical health care provider regarding any health concern or health-related condition you may have.

The statements in this article have not been evaluated by the Food and Drug Administration. The information contained here is not intended to diagnose, treat, cure, or prevent any disease. Suggestions and ideas presented in this document are for information only and should not be interpreted as medical advice, meant for diagnosing illness, or for prescriptive purposes. Readers are encouraged to consult their health care provider before beginning any cleanse, diet, detoxification program, or any supplement regimen. The information in this document is not to be used to replace the services or instructions of a physician or qualified health care practitioner.

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